Acute intermittent porphyria (AIP) is a rare metabolic disorder affecting the production of heme resulting from a deficiency of the enzyme porphobilinogen deaminase. It is the most common of the acute porphyrias.
"}{"slip": { "id": 118, "advice": "A common regret in life is wishing one had the courage to be ones true self."}}
{"fact":"Smuggling a cat out of ancient Egypt was punishable by death. Phoenician traders eventually succeeded in smuggling felines, which they sold to rich people in Athens and other important cities.","length":192}
{"fact":"A cat lover is called an Ailurophilia (Greek: cat+lover).","length":57}
{"fact":"One reason that kittens sleep so much is because a growth hormone is released only during sleep.","length":96}
{"type":"standard","title":"Sivifene","displaytitle":"Sivifene","namespace":{"id":0,"text":""},"wikibase_item":"Q27293750","titles":{"canonical":"Sivifene","normalized":"Sivifene","display":"Sivifene"},"pageid":53754048,"thumbnail":{"source":"https://upload.wikimedia.org/wikipedia/commons/thumb/6/6e/Sivifene.svg/330px-Sivifene.svg.png","width":320,"height":242},"originalimage":{"source":"https://upload.wikimedia.org/wikipedia/commons/thumb/6/6e/Sivifene.svg/1535px-Sivifene.svg.png","width":1535,"height":1160},"lang":"en","dir":"ltr","revision":"1248420691","tid":"0fdce669-7e5c-11ef-90cd-d5ba26837623","timestamp":"2024-09-29T12:12:14Z","description":"Chemical compound","description_source":"local","content_urls":{"desktop":{"page":"https://en.wikipedia.org/wiki/Sivifene","revisions":"https://en.wikipedia.org/wiki/Sivifene?action=history","edit":"https://en.wikipedia.org/wiki/Sivifene?action=edit","talk":"https://en.wikipedia.org/wiki/Talk:Sivifene"},"mobile":{"page":"https://en.m.wikipedia.org/wiki/Sivifene","revisions":"https://en.m.wikipedia.org/wiki/Special:History/Sivifene","edit":"https://en.m.wikipedia.org/wiki/Sivifene?action=edit","talk":"https://en.m.wikipedia.org/wiki/Talk:Sivifene"}},"extract":"Sivifene is a small-molecule antineoplastic agent and immunomodulator that was under development in the 2000s by Tigris Pharmaceuticals as a topical treatment for cutaneous cancer metastases. It was specifically being investigated to treat high-grade squamous intraepithelial lesions (HSIL) associated with human papillomavirus (HPV) infection and invasive carcinomas of the anogenital area such as cervical, vaginal, and anal cancers. The drug reached phase II clinical trials prior to its discontinuation.","extract_html":"
Sivifene is a small-molecule antineoplastic agent and immunomodulator that was under development in the 2000s by Tigris Pharmaceuticals as a topical treatment for cutaneous cancer metastases. It was specifically being investigated to treat high-grade squamous intraepithelial lesions (HSIL) associated with human papillomavirus (HPV) infection and invasive carcinomas of the anogenital area such as cervical, vaginal, and anal cancers. The drug reached phase II clinical trials prior to its discontinuation.
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{"type":"standard","title":"West Columbia, Texas","displaytitle":"West Columbia, Texas","namespace":{"id":0,"text":""},"wikibase_item":"Q979926","titles":{"canonical":"West_Columbia,_Texas","normalized":"West Columbia, Texas","display":"West Columbia, Texas"},"pageid":135552,"thumbnail":{"source":"https://upload.wikimedia.org/wikipedia/commons/thumb/2/23/WestColumbiaTx_%281_of_1%29.jpg/330px-WestColumbiaTx_%281_of_1%29.jpg","width":320,"height":297},"originalimage":{"source":"https://upload.wikimedia.org/wikipedia/commons/2/23/WestColumbiaTx_%281_of_1%29.jpg","width":2495,"height":2315},"lang":"en","dir":"ltr","revision":"1248986703","tid":"9d7737a0-80d5-11ef-991b-4d8886af4cd1","timestamp":"2024-10-02T15:47:23Z","description":"City in Brazoria County, Texas, United States","description_source":"local","coordinates":{"lat":29.14138889,"lon":-95.64694444},"content_urls":{"desktop":{"page":"https://en.wikipedia.org/wiki/West_Columbia%2C_Texas","revisions":"https://en.wikipedia.org/wiki/West_Columbia%2C_Texas?action=history","edit":"https://en.wikipedia.org/wiki/West_Columbia%2C_Texas?action=edit","talk":"https://en.wikipedia.org/wiki/Talk:West_Columbia%2C_Texas"},"mobile":{"page":"https://en.m.wikipedia.org/wiki/West_Columbia%2C_Texas","revisions":"https://en.m.wikipedia.org/wiki/Special:History/West_Columbia%2C_Texas","edit":"https://en.m.wikipedia.org/wiki/West_Columbia%2C_Texas?action=edit","ta